Saikogenin D

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Saikogenin D 分离自Bupleurum chinense ，具有抗炎作用。Saikogenin D 激活环氧合酶，将花生四烯酸转化为环氧二十烷酸和二羟基二十碳三烯酸，其代谢产物继而抑制前列腺素E2(PGE2)的产生。 由于细胞内 Ca2+ 的释放，Saikogenin D导致 [Ca2+]i 升高。

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.

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Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells.Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells.

柴胡皂苷元D

GPCR/G Protein

Prostaglandin Receptor

PGE;Calcium Channel;IL Receptor

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5573-16-0

472.7

C30H48O4

>98% (HPLC)

DMSO : ≥ 100 mg/mL (211.55 mM; )

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(-20℃)

With Ice Pack

≥ 2 years